What is the PreTRM® Test?
The first and only clinically validated blood-based biomarker test that identifies a woman’s individual risk of spontaneous preterm birth — even if she has no known risk factors.
The PreTRM® Test is supported by multiple peer-reviewed studies, including PRIME and AVERT PRETERM, showing that early risk identification paired with targeted preventive interventions significantly improves maternal and neonatal outcomes. 1,2
UNDERSTANDING RISK EARLY
Many women who experience spontaneous preterm birth have no known clinical risk factors and no warning signs.3 Traditional prenatal screening methods provide important information but cannot identify all at-risk pregnancies. Even those who appear low risk may still carry underlying biological risk.
Earlier insight into risk gives obstetric providers the opportunity to personalize care and monitoring before symptoms begin.
TURNING INSIGHT INTO PROACTIVE CARE
The PreTRM® Test was developed after it was discovered that specific proteins (biomarkers) in a mother’s blood can signal increased risk for spontaneous preterm birth.
By measuring two key proteins alongside clinical information, the PreTRM® Test helps identify pregnancies at higher risk, allowing for proactive care and pregnancy management before warning signs appear.4
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References
- Iriye BK, O’Brien JM, Ennen CS, et al. Neonatal impact of maternal biomarker screening for risk of preterm birth with targeted interventions (PRIME): A multicenter, randomized, controlled trial. Pregnancy 2026;2(1):e70202. DOI: https://doi.org/10.1002/pmf2.70202
- Hoffman MK, Kitto C, Zhang Z, Shi J, Walker MG, Shahbaba B, Ruhstaller K. Neonatal Outcomes after Maternal Biomarker-Guided Preterm Birth Intervention: The AVERT PRETERM Trial. Diagnostics. 2024; 14(14):1462. https://doi.org/10.3390/diagnostics14141462
- Iams, JD. Clinical Practice. Prevention of preterm parturition. N Engl J Med. 2014;370:254-61.
- American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Obstetrics. Prediction and Prevention of Spontaneous Preterm Birth: ACOG Practice Bulletin, Number 234. Obstet Gynecol 2021;138(2):e65–e90. DOI: 10.1097/AOG.0000000000004479.
- Polpitiya A, Cox C, Butler H, et al. Integrating clinical factors and parity-specific models with molecular biomarkers to better predict the risk of preterm birth in asymptomatic women. medRxiv 2026:2026.03.13.26348357. DOI: 10.64898/2026.03.13.26348357.